Inicio Nature Weight problems alters pathology and therapy response in inflammatory illness

Weight problems alters pathology and therapy response in inflammatory illness

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  • Buck, M. D., Sowell, R. T., Kaech, S. M. & Pearce, E. L. Metabolic instruction of immunity. Cell 169, 570–586 (2017).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Man, Okay., Kutyavin, V. I. & Chawla, A. Tissue immunometabolism: growth, physiology, and pathobiology. Cell Metab. 25, 11–26 (2017).

    CAS 
    PubMed 

    Google Scholar
     

  • Geltink, R. I. Okay., Kyle, R. L. & Pearce, E. L. Unraveling the advanced interaction between T cell metabolism and performance. Annu. Rev. Immunol. 36, 461–488 (2018).

    CAS 
    PubMed 

    Google Scholar
     

  • Michelet, X. et al. Metabolic reprogramming of pure killer cells in weight problems limits antitumor responses. Nat. Immunol. 19, 1330–1640 (2018).

    CAS 
    PubMed 

    Google Scholar
     

  • Nicholas, D. A. et al. Fatty acid metabolites mix with diminished β-oxidation to activate Th17 irritation in human sort 2 diabetes. Cell Metab. 30, 447–461.e5 (2019).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ringel, A. E. et al. Weight problems shapes metabolism within the tumor microenvironment to suppress anti-tumor immunity. Cell 183, 1848–1866.e26 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang, C. et al. STAT3 activation-induced fatty acid oxidation in CD8+ T effector cells is important for obesity-promoted breast tumor progress. Cell Metab. 31, 148–161.e5 (2020).

    CAS 
    PubMed 

    Google Scholar
     

  • Hersoug, L. G. & Linneberg, A. The hyperlink between the epidemics of weight problems and allergic illnesses: does weight problems induce decreased immune tolerance? Allergy 62, 1205–1213 (2007).

    CAS 
    PubMed 

    Google Scholar
     

  • Wenzel, S. E. Bronchial asthma phenotypes: the evolution from medical to molecular approaches. Nat. Med. 18, 716–725 (2012).

    CAS 
    PubMed 

    Google Scholar
     

  • Zhang, A. & Silverberg, J. I. Affiliation of atopic dermatitis with being obese and overweight: a scientific evaluate and metaanalysis. J. Am. Acad. Dermatol. 72, 606–616.e4 (2015).

    PubMed 

    Google Scholar
     

  • Fahy, J. V. Sort 2 irritation in bronchial asthma—current in most, absent in lots of. Nat. Rev. Immunol. 15, 57–65 (2015).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bieber, T. Atopic Dermatitis. New Engl. J. Med. 358, 1483–1494 (2008).

    CAS 
    PubMed 

    Google Scholar
     

  • Eckert, L. et al. The burden of atopic dermatitis in US adults: well being care useful resource utilization knowledge from the 2013 Nationwide Well being and Wellness Survey. J. Am. Acad. Dermatol. 78, 54–61.e1 (2018).

  • Li, M. et al. Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and set off an atopic dermatitis. Proc. Natl Acad. Sci. USA 103, 11736–11741 (2006).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Leyva-Castillo, J. M. et al. Pores and skin thymic stromal lymphopoietin initiates Th2 responses by way of an orchestrated immune cascade. Nat. Commun. 4, 2847 (2015).

    ADS 

    Google Scholar
     

  • Swindell, W. R. et al. Heterogeneity of inflammatory and cytokine networks in persistent plaque psoriasis. PLoS ONE 7, e34594 (2012).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chiricozzi, A. et al. Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. J. Make investments. Dermatol. 131, 677–687 (2011).

    CAS 
    PubMed 

    Google Scholar
     

  • Hastie, A. T. et al. Baseline sputum eosinophil 1 neutrophil subgroups’ medical traits and longitudinal trajectories for NHLBI Extreme Bronchial asthma Analysis Program (SARP 3) cohort. J. Allergy Clin. Immunol. 146, 222–226 (2020).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kuruvilla, M. E., Lee, F. E.-H. & Lee, G. B. Understanding bronchial asthma phenotypes, endotypes, and mechanisms of illness. Clin. Rev. Allerg. Immuol. 56, 219–233 (2019).


    Google Scholar
     

  • Winer, S. et al. Weight problems predisposes to Th17 bias. Eur. J. Immunol. 39, 2629–2635 (2009).

    CAS 
    PubMed 

    Google Scholar
     

  • Endo, Y. et al. Weight problems drives Th17 cell differentiation by inducing the lipid metabolic kinase ACC1. Cell Rep. 12, 1042–1055 (2015).

    CAS 
    PubMed 

    Google Scholar
     

  • Manno, G. L. et al. RNA velocity of single cells. Nature 560, 494–498 (2018).

    ADS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bergen, V., Lange, M., Peidli, S., Wolf, F. A. & Theis, F. J. Generalizing RNA velocity to transient cell states by way of dynamical modeling. Nat. Biotechnol. 38, 1408–1414 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Becht, E. et al. Dimensionality discount for visualizing single-cell knowledge utilizing UMAP. Nat. Biotechnol. 37, 38–44 (2018).


    Google Scholar
     

  • McInnes, L., Healy, J. & Melville, J. UMAP: uniform manifold approximation and projection for dimension discount. Preprint at https://doi.org/10.48550/arXiv.1802.03426 (2018).

  • Gooderham, M. J. et al. Dupilumab: A evaluate of its use within the therapy of atopic dermatitis. J. Am. Acad. Dermatol. 78, S28–S36 (2018).

    CAS 
    PubMed 

    Google Scholar
     

  • Hearn, A. P., Kent, B. D. & Jackson, D. J. Biologic therapy choices for extreme bronchial asthma. Curr. Opin. Immunol. 66, 151–160 (2020).

    CAS 
    PubMed 

    Google Scholar
     

  • Tubau, C. & Puig, L. Therapeutic focusing on of the IL-13 pathway in pores and skin irritation. Professional Rev. Clin. Immunol. 17, 15–25 (2021).

    CAS 
    PubMed 

    Google Scholar
     

  • Laidlaw, T. M. et al. Dupilumab improves upper- and lower-airway illness management in persistent rhinosinusitis with nasal polyps and bronchial asthma. Ann. Allergy Bronchial asthma Immunol. 126, 584–592.e1 (2021).

    CAS 
    PubMed 

    Google Scholar
     

  • Rosen, E. D. & Spiegelman, B. M. PPARγ: a nuclear regulator of metabolism, differentiation, and cell progress. J. Biol. Chem. 276, 37731–37734 (2001).

    CAS 
    PubMed 

    Google Scholar
     

  • Tontonoz, P. & Spiegelman, B. M. Fats and past: the various biology of PPARγ. Annu. Rev. Biochem. 77, 289–312 (2008).

    CAS 
    PubMed 

    Google Scholar
     

  • Ahmadian, M. et al. PPARγ signaling and metabolism: the nice, the unhealthy and the long run. Nat. Med. 19, 557–566 (2013).

    CAS 
    PubMed 

    Google Scholar
     

  • Lazar, M. A. Maturing of the nuclear receptor household. J. Clin. Make investments. 127, 1123–1125 (2017).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Henriksson, J. et al. Genome-wide CRISPR screens in T helper cells reveal pervasive crosstalk between activation and differentiation. Cell 176, 882–896.e18 (2019).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Woerly, G. et al. Peroxisome proliferator-activated receptors α and γ down-regulate allergic irritation and eosinophil activation. J. Exp. Med. 198, 411–421 (2003).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Honda, Okay., Marquillies, P., Capron, M. & Dombrowicz, D. Peroxisome proliferator–activated receptor γ is expressed in airways and inhibits options of airway transforming in a mouse bronchial asthma mannequin. J. Allergy Clin. Immunol. 113, 882–888 (2004).

    CAS 
    PubMed 

    Google Scholar
     

  • Hammad, H. et al. Activation of peroxisome proliferator-activated receptor-γ in dendritic cells inhibits the event of eosinophilic airway irritation in a mouse mannequin of bronchial asthma. Am. J. Pathol. 164, 263–271 (2004).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee, Okay. S. et al. Modulation of airway transforming and airway irritation by peroxisome proliferator-activated receptor γ in a murine mannequin of toluene diisocyanate-induced bronchial asthma. J. Immunol. 177, 5248–5257 (2006).

    CAS 
    PubMed 

    Google Scholar
     

  • Chen, T. et al. PPAR-γ promotes sort 2 immune responses in allergy and nematode an infection. Sci. Immunol. 2, eaal5196 (2017).

    PubMed 

    Google Scholar
     

  • Nobs, S. P. et al. PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung irritation. J. Exp. Med. 214, 3015–3035 (2017).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Stark, J. M., Tibbitt, C. A. & Coquet, J. M. The metabolic necessities of Th2 cell differentiation. Entrance. Immunol. 10, 2318 (2019).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Klotz, L. et al. The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell-intrinsic trend and suppresses CNS autoimmunity. J. Exp. Med. 206, 2079–2089 (2009).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bapat, S. P. et al. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528, 137–141 (2015).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • NCD-RisC. Traits in grownup body-mass index in 200 nations from 1975 to 2014: a pooled evaluation of 1698 population-based measurement research with 19·2 million individuals. Lancet 387, 1377–1396 (2016).


    Google Scholar
     

  • The GBD 2015 Weight problems Collaborators. Well being results of obese and weight problems in 195 nations over 25 years. N. Engl. J. Med. 377, 13–27 (2017).


    Google Scholar
     

  • Abarca-Gómez, L. et al. Worldwide tendencies in body-mass index, underweight, obese, and weight problems from 1975 to 2016: a pooled evaluation of 2416 population-based measurement research in 128.9 million youngsters, adolescents, and adults. Lancet 390, 2627–2642 (2017).


    Google Scholar
     

  • Lucas, C. et al. Longitudinal analyses reveal immunological misfiring in extreme COVID-19. Nature 584, 463–469 (2020).

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liston, A. et al. Differentiation of regulatory Foxp3+ T cells within the thymic cortex. Proc. Natl Acad. Sci. USA 105, 11903–11908 (2008).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lee, P. P. et al. A important position for Dnmt1 and DNA methylation in T cell growth, perform, and survival. Immunity 15, 763–774 (2001).

    CAS 
    PubMed 

    Google Scholar
     

  • He, W. Adipose-specific peroxisome proliferator-activated receptor  knockout causes insulin resistance in fats and liver however not in muscle. Proc. Natl Acad. Sci. USA 100, 15712–15717 (2003).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rubtsov, Y. P. et al. Regulatory T cell-derived interleukin-10 limits irritation at environmental interfaces. Immunity 28, 546–558 (2008).

    CAS 
    PubMed 

    Google Scholar
     

  • Hastie, A. T. et al. Blended sputum granulocyte longitudinal affect on lung perform within the extreme bronchial asthma analysis program. Am. J. Resp. Crit. Care 203, 882–892 (2021).

    CAS 

    Google Scholar
     

  • Wolf, F. A., Angerer, P. & Theis, F. J. SCANPY: large-scale single-cell gene expression knowledge evaluation. Genome Biol. 19, 15 (2018).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Traag, V. A., Waltman, L. & Eck, N. J. V. From Louvain to Leiden: guaranteeing well-connected communities. Sci. Rep. 9, 5233 (2019).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dobin, A. et al. STAR: ultrafast common RNA-seq aligner. Bioinformatics 29, 15–21 (2012).

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Trapnell, C. et al. Differential evaluation of gene regulation at transcript decision with RNA-seq. Nat. Biotechnol. 31, 46–53 (2012).

    PubMed 

    Google Scholar
     

  • Roberts, A., Pimentel, H., Trapnell, C. & Pachter, L. Identification of novel transcripts in annotated genomes utilizing RNA-seq. Bioinformatics 27, 2325–2329 (2011).

    CAS 
    PubMed 

    Google Scholar
     

  • Cho, H. et al. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β. Nature 485, 123–127 (2012).

    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

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